The Global Fabry Disease Treatment Market Size accounted for USD 1.7 Billion in 2023 and is estimated to achieve a market size of USD 3.2 Billion by 2032 growing at a CAGR of 7.9% from 2024 to 2032.
Fabry Disease Treatment Market Highlights
- Global fabry disease treatment market revenue is poised to garner USD 3.2 billion by 2032 with a CAGR of 7.9% from 2024 to 2032
- North America fabry disease treatment market value occupied around USD 561 million in 2023
- Asia Pacific fabry disease treatment market growth will record a CAGR of more than 9% from 2024 to 2032
- Among treatment, the enzyme replacement therapy (ERT) sub-segment generated 65% of the market share in 2023
- Based on route of administration, the intravenous route sub-segment generated significant market share in 2023
- Increasing research in gene therapy as a potential cure is the fabry disease treatment market trend that fuels the industry demand
Fabry disease is a rare inherited lysosomal storage disorder caused by a genetic mutation that affects the function of the alpha-galactosidase enzyme. The disease typically presents with late-onset, mild symptoms, leading to many cases going undiagnosed. The standard treatment for managing fabry disease is enzyme replacement therapy (ERT). Sanofi's Fabrazyme and Shire's Replagal are the only approved ERTs in the EU; however, in the U.S., only Fabrazyme has received approval. The growing number of Fabry disease cases, the expanding use of novel treatments such as chaperone therapy, and the potential approval of pipeline drugs, including substrate reduction therapies and enzyme replacement therapies, are driving significant growth in the market.
Global Fabry Disease Treatment Market Dynamics
Market Drivers
- Increasing awareness and diagnosis rates of rare diseases like fabry
- Advancements in gene therapy and personalized medicine
- Growing investments in R&D by pharmaceutical companies
Market Restraints
- High cost of treatment and limited access to therapies
- Regulatory challenges and lengthy approval processes
- Limited patient pool due to the rarity of the disease
Market Opportunities
- Expansion of treatment options with innovative gene and enzyme replacement therapies
- Growth potential in emerging markets with improving healthcare infrastructure
- Collaboration between biotech firms and academic institutions for drug development
Fabry Disease Treatment Market Report Coverage
Market |
Fabry Disease Treatment Market |
Fabry Disease Treatment Market Size 2022 |
USD 1.7 Billion
|
Fabry Disease Treatment Market Forecast 2032 |
USD 3.2 Billion |
Fabry Disease Treatment Market CAGR During 2023 - 2032 |
7.9% |
Fabry Disease Treatment Market Analysis Period |
2020 - 2032 |
Fabry Disease Treatment Market Base Year
|
2022 |
Fabry Disease Treatment Market Forecast Data |
2023 - 2032 |
Segments Covered |
By Technology, By Route Of Administration, By Distribution Channel, And By Geography
|
Regional Scope |
North America, Europe, Asia Pacific, Latin America, and Middle East & Africa |
Key Companies Profiled |
Green Cross Pharma Pte Ltd., Amicus Therapeutics Inc., Sanofi S.A., Moderna Therapeutics Inc., Protalix Biotherapeutics Inc., ISU Abxis Co Ltd., Idorsia Pharmaceuticals Ltd, Takeda Pharmaceutical Company Limited, and JCR Pharmaceuticals Co Ltd. |
Report Coverage
|
Market Trends, Drivers, Restraints, Competitive Analysis, Player Profiling, Covid-19 Analysis, Regulation Analysis |
Fabry Disease Treatment Market Insights
The growing number of patients with fabry disease, coupled with the increasing adoption of novel treatments such as chaperone therapy, has driven significant momentum in the market. Additionally, extensive research and development activities, along with the potential approval of promising pipeline products like substrate reduction therapies and enzyme replacement therapies, are expected to further fuel fabry disease treatment market growth over the forecast period.
Fabry disease is a rare X-linked lysosomal storage disorder characterized by a deficiency of the alpha-galactosidase enzyme, leading to progressive organ dysfunction. This condition is caused by the abnormal accumulation of a specific fatty substance called globotriaosylceramide in various tissues throughout the body, including the eyes, skin, kidneys, gastrointestinal system, central nervous system, heart, and brain.
Patients with fabry disease often experience severe pain in the extremities, compromised kidney function that can progress to full kidney failure, early heart problems, stroke, and debilitating gastrointestinal symptoms. Due to the lack of a curative treatment for fabry disease, current therapeutic options primarily focus on managing complications associated with disease progression and providing symptomatic relief.
Fabry Disease Treatment Market Segmentation
The worldwide market for fabry disease treatment is split based on treatment, route of administration, distribution channel, and geography.
Fabry Disease Treatment Type
- Enzyme Replacement Therapy (ERT)
- Chaperone Treatment
- Substrate Reduction Therapy (SRT)
- Others
According to the fabry disease treatment industry analysis, enzyme replacement therapy (ERT) is the dominant treatment because it directly addresses the enzyme deficiency caused by the genetic disorder. By supplementing the missing or deficient alpha-galactosidase an enzyme, ERT helps reduce the accumulation of harmful substances in cells, alleviating symptoms and slowing disease progression. Its efficacy in managing the disease and improving patient outcomes has made it the standard of care in the fabry disease treatment market.
Fabry Disease Treatment Route of Administration
- Intravenous Route
- Oral Route
The intravenous route segment is the largest route of administration category in the fabry disease treatment market, due to its effectiveness in delivering enzyme replacement therapies (ERTs) directly into the bloodstream. IV administration ensures optimal bioavailability, allowing the therapeutic enzymes to reach target tissues efficiently. This method is preferred for managing the disease's systemic effects and is essential for achieving consistent and controlled therapeutic outcomes.
Fabry Disease Treatment Distribution Channel
- Hospital Pharmacy
- Retail Pharmacy
- Online Pharmacy
According to the fabry disease treatment industry forecast, hospital pharmacies dominate as the primary distribution channel due to their role in managing complex therapies that often require specialized handling and administration. Patients with fabry disease typically receive enzyme replacement therapies or other advanced treatments that need to be administered under medical supervision, making hospital pharmacies essential.
Fabry Disease Treatment Market Regional Outlook
North America
Europe
- U.K.
- Germany
- France
- Spain
- Rest of Europe
Asia-Pacific
- India
- Japan
- China
- Australia
- South Korea
- Rest of Asia-Pacific
Latin America
- Brazil
- Mexico
- Rest of Latin America
The Middle East & Africa
- South Africa
- GCC Countries
- Rest of the Middle East & Africa (ME&A)
Fabry Disease Treatment Market Regional Analysis
For several reasons, North America was the leading regional market, followed by Europe. The adoption of novel therapies, superior healthcare facilities, and favorable reimbursement policies are key factors driving market growth in these regions. Additionally, the inclusion of expensive medications like fabrazyme in health insurance programs and supportive government healthcare policies are encouraging pharmaceutical companies to boost R&D efforts in the area of rare diseases.
The Asia-Pacific region offers significant growth opportunities for pharmaceutical companies, driven by increasing healthcare expenditures and improving infrastructure. This region is expected to experience the fastest growth in the coming years, followed by Latin America, largely due to the substantial populations in emerging countries.
Fabry Disease Treatment Market Players
Some of the top fabry disease treatment companies offered in our report include Green Cross Pharma Pte Ltd., Amicus Therapeutics Inc., Sanofi S.A., Moderna Therapeutics Inc., Protalix Biotherapeutics Inc., ISU Abxis Co Ltd., Idorsia Pharmaceuticals Ltd, Takeda Pharmaceutical Company Limited, and JCR Pharmaceuticals Co Ltd.
CHAPTER 1. Industry Overview of Fabry Disease Treatment Market
1.1. Definition and Scope
1.1.1. Definition of Fabry Disease Treatment
1.1.2. Market Segmentation
1.1.3. Years Considered for the Study
1.1.4. Assumptions and Acronyms Used
1.1.4.1. Market Assumptions and Market Forecast
1.1.4.2. Acronyms Used in Global Fabry Disease Treatment Market
1.2. Summary
1.2.1. Executive Summary
1.2.2. Fabry Disease Treatment Market By Treatment
1.2.3. Fabry Disease Treatment Market By Route of Administration
1.2.4. Fabry Disease Treatment Market By Distribution Channel
1.2.5. Fabry Disease Treatment Market By Region
CHAPTER 2. Research Approach
2.1. Methodology
2.1.1. Research Programs
2.1.2. Market Size Estimation
2.1.3. Market Breakdown and Data Triangulation
2.2. Data Source
2.2.1. Secondary Sources
2.2.2. Primary Sources
CHAPTER 3. Market Dynamics And Competition Analysis
3.1. Market Drivers
3.1.1. Driver 1
3.1.2. Driver 2
3.1.3. Driver 3
3.2. Restraints and Challenges
3.2.1. Restraint 1
3.2.2. Restraint 2
3.2.3. Restraint 3
3.3. Growth Opportunities
3.3.1. Opportunity 1
3.3.2. Opportunity 2
3.3.3. Opportunity 3
3.4. Porter’s Five Forces Analysis
3.4.1. Bargaining Power of Suppliers
3.4.2. Bargaining Power of Buyers
3.4.3. Threat of Substitute
3.4.4. Threat of New Entrants
3.4.5. Degree of Competition
3.5. Market Concentration Ratio and Market Maturity Analysis of Fabry Disease Treatment Market
3.5.1. Go To Market Strategy
3.5.1.1. Introduction
3.5.1.2. Growth
3.5.1.3. Maturity
3.5.1.4. Saturation
3.5.1.5. Possible Development
3.6. Technological Roadmap for Fabry Disease Treatment Market
3.7. Value Chain Analysis
3.7.1. List of Key Manufacturers
3.7.2. List of Customers
3.7.3. Level of Integration
3.8. Regulatory Compliance
3.9. Competitive Landscape, 2023
3.9.1. Player Positioning Analysis
3.9.2. Key Strategies Adopted By Leading Players
CHAPTER 4. Manufacturing Plant Analysis
4.1. Manufacturing Plant Location and Establish Date of Major Manufacturers in 2023
4.2. R&D Status of Major Manufacturers in 2023
CHAPTER 5. Fabry Disease Treatment Market By Treatment
5.1. Introduction
5.2. Fabry Disease Treatment Revenue By Treatment
5.2.1. Fabry Disease Treatment Revenue (USD Billion) and Forecast, By Treatment, 2020-2032
5.2.2. Enzyme Replacement Therapy (ERT)
5.2.2.1. Enzyme Replacement Therapy (ERT) Market Revenue (USD Billion) and Growth Rate (%), 2020-2032
5.2.3. Chaperone Treatment
5.2.3.1. Chaperone Treatment Market Revenue (USD Billion) and Growth Rate (%), 2020-2032
5.2.4. Substrate Reduction Therapy (SRT)
5.2.4.1. Substrate Reduction Therapy (SRT) Market Revenue (USD Billion) and Growth Rate (%), 2020-2032
5.2.5. Others
5.2.5.1. Others Market Revenue (USD Billion) and Growth Rate (%), 2020-2032
CHAPTER 6. Fabry Disease Treatment Market By Route of Administration
6.1. Introduction
6.2. Fabry Disease Treatment Revenue By Route of Administration
6.2.1. Fabry Disease Treatment Revenue (USD Billion) and Forecast, By Route of Administration, 2020-2032
6.2.2. Intravenous Route
6.2.2.1. Intravenous Route Market Revenue (USD Billion) and Growth Rate (%), 2020-2032
6.2.3. Oral Route
6.2.3.1. Oral Route Market Revenue (USD Billion) and Growth Rate (%), 2020-2032
CHAPTER 7. Fabry Disease Treatment Market By Distribution Channel
7.1. Introduction
7.2. Fabry Disease Treatment Revenue By Distribution Channel
7.2.1. Fabry Disease Treatment Revenue (USD Billion) and Forecast, By Distribution Channel, 2020-2032
7.2.2. Hospital Pharmacy
7.2.2.1. Hospital Pharmacy Market Revenue (USD Billion) and Growth Rate (%), 2020-2032
7.2.3. Retail Pharmacy
7.2.3.1. Retail Pharmacy Market Revenue (USD Billion) and Growth Rate (%), 2020-2032
7.2.4. Online Pharmacy
7.2.4.1. Online Pharmacy Market Revenue (USD Billion) and Growth Rate (%), 2020-2032
CHAPTER 8. North America Fabry Disease Treatment Market By Country
8.1. North America Fabry Disease Treatment Market Overview
8.2. U.S.
8.2.1. U.S. Fabry Disease Treatment Revenue (USD Billion) and Forecast By Treatment, 2020-2032
8.2.2. U.S. Fabry Disease Treatment Revenue (USD Billion) and Forecast By Route of Administration, 2020-2032
8.2.3. U.S. Fabry Disease Treatment Revenue (USD Billion) and Forecast By Distribution Channel, 2020-2032
8.3. Canada
8.3.1. Canada Fabry Disease Treatment Revenue (USD Billion) and Forecast By Treatment, 2020-2032
8.3.2. Canada Fabry Disease Treatment Revenue (USD Billion) and Forecast By Route of Administration, 2020-2032
8.3.3. Canada Fabry Disease Treatment Revenue (USD Billion) and Forecast By Distribution Channel, 2020-2032
8.4. North America PEST Analysis
CHAPTER 9. Europe Fabry Disease Treatment Market By Country
9.1. Europe Fabry Disease Treatment Market Overview
9.2. U.K.
9.2.1. U.K. Fabry Disease Treatment Revenue (USD Billion) and Forecast By Treatment, 2020-2032
9.2.2. U.K. Fabry Disease Treatment Revenue (USD Billion) and Forecast By Route of Administration, 2020-2032
9.2.3. U.K. Fabry Disease Treatment Revenue (USD Billion) and Forecast By Distribution Channel, 2020-2032
9.3. Germany
9.3.1. Germany Fabry Disease Treatment Revenue (USD Billion) and Forecast By Treatment, 2020-2032
9.3.2. Germany Fabry Disease Treatment Revenue (USD Billion) and Forecast By Route of Administration, 2020-2032
9.3.3. Germany Fabry Disease Treatment Revenue (USD Billion) and Forecast By Distribution Channel, 2020-2032
9.4. France
9.4.1. France Fabry Disease Treatment Revenue (USD Billion) and Forecast By Treatment, 2020-2032
9.4.2. France Fabry Disease Treatment Revenue (USD Billion) and Forecast By Route of Administration, 2020-2032
9.4.3. France Fabry Disease Treatment Revenue (USD Billion) and Forecast By Distribution Channel, 2020-2032
9.5. Spain
9.5.1. Spain Fabry Disease Treatment Revenue (USD Billion) and Forecast By Treatment, 2020-2032
9.5.2. Spain Fabry Disease Treatment Revenue (USD Billion) and Forecast By Route of Administration, 2020-2032
9.5.3. Spain Fabry Disease Treatment Revenue (USD Billion) and Forecast By Distribution Channel, 2020-2032
9.6. Rest of Europe
9.6.1. Rest of Europe Fabry Disease Treatment Revenue (USD Billion) and Forecast By Treatment, 2020-2032
9.6.2. Rest of Europe Fabry Disease Treatment Revenue (USD Billion) and Forecast By Route of Administration, 2020-2032
9.6.3. Rest of Europe Fabry Disease Treatment Revenue (USD Billion) and Forecast By Distribution Channel, 2020-2032
9.7. Europe PEST Analysis
CHAPTER 10. Asia Pacific Fabry Disease Treatment Market By Country
10.1. Asia Pacific Fabry Disease Treatment Market Overview
10.2. China
10.2.1. China Fabry Disease Treatment Revenue (USD Billion) and Forecast By Treatment, 2020-2032
10.2.2. China Fabry Disease Treatment Revenue (USD Billion) and Forecast By Route of Administration, 2020-2032
10.2.3. China Fabry Disease Treatment Revenue (USD Billion) and Forecast By Distribution Channel, 2020-2032
10.3. Japan
10.3.1. Japan Fabry Disease Treatment Revenue (USD Billion) and Forecast By Treatment, 2020-2032
10.3.2. Japan Fabry Disease Treatment Revenue (USD Billion) and Forecast By Route of Administration, 2020-2032
10.3.3. Japan Fabry Disease Treatment Revenue (USD Billion) and Forecast By Distribution Channel, 2020-2032
10.4. India
10.4.1. India Fabry Disease Treatment Revenue (USD Billion) and Forecast By Treatment, 2020-2032
10.4.2. India Fabry Disease Treatment Revenue (USD Billion) and Forecast By Route of Administration, 2020-2032
10.4.3. India Fabry Disease Treatment Revenue (USD Billion) and Forecast By Distribution Channel, 2020-2032
10.5. Australia
10.5.1. Australia Fabry Disease Treatment Revenue (USD Billion) and Forecast By Treatment, 2020-2032
10.5.2. Australia Fabry Disease Treatment Revenue (USD Billion) and Forecast By Route of Administration, 2020-2032
10.5.3. Australia Fabry Disease Treatment Revenue (USD Billion) and Forecast By Distribution Channel, 2020-2032
10.6. South Korea
10.6.1. South Korea Fabry Disease Treatment Revenue (USD Billion) and Forecast By Treatment, 2020-2032
10.6.2. South Korea Fabry Disease Treatment Revenue (USD Billion) and Forecast By Route of Administration, 2020-2032
10.6.3. South Korea Fabry Disease Treatment Revenue (USD Billion) and Forecast By Distribution Channel, 2020-2032
10.7. Rest of Asia-Pacific
10.7.1. Rest of Asia-Pacific Fabry Disease Treatment Revenue (USD Billion) and Forecast By Treatment, 2020-2032
10.7.2. Rest of Asia-Pacific Fabry Disease Treatment Revenue (USD Billion) and Forecast By Route of Administration, 2020-2032
10.7.3. Rest of Asia-Pacific Fabry Disease Treatment Revenue (USD Billion) and Forecast By Distribution Channel, 2020-2032
10.8. Asia Pacific PEST Analysis
CHAPTER 11. Latin America Fabry Disease Treatment Market By Country
11.1. Latin America Fabry Disease Treatment Market Overview
11.2. Brazil
11.2.1. Brazil Fabry Disease Treatment Revenue (USD Billion) and Forecast By Treatment, 2020-2032
11.2.2. Brazil Fabry Disease Treatment Revenue (USD Billion) and Forecast By Route of Administration, 2020-2032
11.2.3. Brazil Fabry Disease Treatment Revenue (USD Billion) and Forecast By Distribution Channel, 2020-2032
11.3. Mexico
11.3.1. Mexico Fabry Disease Treatment Revenue (USD Billion) and Forecast By Treatment, 2020-2032
11.3.2. Mexico Fabry Disease Treatment Revenue (USD Billion) and Forecast By Route of Administration, 2020-2032
11.3.3. Mexico Fabry Disease Treatment Revenue (USD Billion) and Forecast By Distribution Channel, 2020-2032
11.4. Rest of Latin America
11.4.1. Rest of Latin America Fabry Disease Treatment Revenue (USD Billion) and Forecast By Treatment, 2020-2032
11.4.2. Rest of Latin America Fabry Disease Treatment Revenue (USD Billion) and Forecast By Route of Administration, 2020-2032
11.4.3. Rest of Latin America Fabry Disease Treatment Revenue (USD Billion) and Forecast By Distribution Channel, 2020-2032
11.5. Latin America PEST Analysis
CHAPTER 12. Middle East & Africa Fabry Disease Treatment Market By Country
12.1. Middle East & Africa Fabry Disease Treatment Market Overview
12.2. GCC
12.2.1. GCC Fabry Disease Treatment Revenue (USD Billion) and Forecast By Treatment, 2020-2032
12.2.2. GCC Fabry Disease Treatment Revenue (USD Billion) and Forecast By Route of Administration, 2020-2032
12.2.3. GCC Fabry Disease Treatment Revenue (USD Billion) and Forecast By Distribution Channel, 2020-2032
12.3. South Africa
12.3.1. South Africa Fabry Disease Treatment Revenue (USD Billion) and Forecast By Treatment, 2020-2032
12.3.2. South Africa Fabry Disease Treatment Revenue (USD Billion) and Forecast By Route of Administration, 2020-2032
12.3.3. South Africa Fabry Disease Treatment Revenue (USD Billion) and Forecast By Distribution Channel, 2020-2032
12.4. Rest of Middle East & Africa
12.4.1. Rest of Middle East & Africa Fabry Disease Treatment Revenue (USD Billion) and Forecast By Treatment, 2020-2032
12.4.2. Rest of Middle East & Africa Fabry Disease Treatment Revenue (USD Billion) and Forecast By Route of Administration, 2020-2032
12.4.3. Rest of Middle East & Africa Fabry Disease Treatment Revenue (USD Billion) and Forecast By Distribution Channel, 2020-2032
12.5. Middle East & Africa PEST Analysis
CHAPTER 13. Player Analysis Of Fabry Disease Treatment Market
13.1. Fabry Disease Treatment Market Company Share Analysis
13.2. Competition Matrix
13.2.1. Competitive Benchmarking of key players by price, presence, market share, and R&D investment
13.2.2. New Product Launches and Product Enhancements
13.2.3. Mergers And Acquisition In Global Fabry Disease Treatment Market
13.2.4. Partnership, Joint Ventures and Strategic Alliances/ Sales Agreements
CHAPTER 14. Company Profile
14.1. Green Cross Pharma Pte Ltd.
14.1.1. Company Snapshot
14.1.2. Business Overview
14.1.3. Financial Overview
14.1.3.1. Revenue (USD Billion), 2023
14.1.3.2. Green Cross Pharma Pte Ltd., 2023 Fabry Disease Treatment Business Regional Distribution
14.1.4. Product /Service and Specification
14.1.5. Recent Developments & Business Strategy
14.2. Amicus Therapeutics Inc.
14.3. Sanofi S.A.
14.4. Moderna Therapeutics Inc.
14.5. Protalix Biotherapeutics Inc.
14.6. ISU Abxis Co Ltd.
14.7. Idorsia Pharmaceuticals Ltd
14.8. Takeda Pharmaceutical Company Limited
14.9. JCR Pharmaceuticals Co Ltd.