The global peptide synthesis market is expected to grow at significant CAGR of 6.6% over the forecast period 2019 to 2026 and reach around more than USD 400 million by 2026.

Peptides are organic molecules of a peptide (amide) bound amino acids. Peptide synthesis is the mechanism by which a carboxylic acid from one amino acid is compressed into the amino group of another, forming short sequences of peptides. The production of advanced peptide synthesizers is expected to drive market growth, such as increased use of peptides in pharmaceutical medicinal products, increased research activities, and availability of funds for R & D. The lack of a standardized set of rules for therapeutic peptides, however, is expected during the forecast period to limit the growth of this market.

While chemical synthesis is the most mature technology to synthesize peptide, lacking specificity and environmental impact are serious disadvantages that enzyme biocatalysis can in theory succeed in overcoming. Nonetheless, enzyme synthesis efficiency is lower. Biocatalyst cost is usually high and no validation and expansion protocols exist that reflect challenges which are actively faced by intensive research and development in this field.

Market Insights

To carry out the coupling reactions, multiple reagents are added to activate the amino acid carboxyl groups. Most of them include hydroxybenzotriazole (HOBT), phosphonium salts, and uranium. N-methylpirrolidone, dimethylacetamide, Chaotropic salts, and mixture of solvents are used in difficult sequences to improve binding performance and the elongation of the peptide chain. Sequence synthesis, chemical binding, and convergent synthesis are the main solid phase peptide synthesis (SPPS) techniques.

Cells need a variety of chemical subsystems, including functionally supported peptides, split lipids and many small other molecules that form the basis of metabolization.

All species contain 7,000 natural peptides that have a large role in the biology of bacteria, plants, animals and people. Peptides and proteins are well known to be highly specific and powerful to their natural aim and to have a good human safety profile. This makes them a great choice for developing new biopharmaceutical products. Unmodified peptides and proteins often have short half-lives in blood due to kidney clearance, proteolytic degradation or specific absorption by the receptor. Synthetic peptides are rapidly growing. Such molecules are commonly used for work in biomedicine, biology, or the cosmetics industry. The peptide pharmaceuticals market today stands at USD 15 billion. The downside of peptide processing is the vast amounts of toxic organic solvents (DCM) and DIMF, used in significant abundance for both solvent syntheses and solid-phase peptide synthesis.

Major Classes Of Peptides

Class	Source	Application
Ribosomal Peptides	mRNA translation	Antibiotics, Hormones, Signaling peptides, Bacteriocins
Non-Ribosomal Peptides	Non-ribosomal peptide synthetases	Toxins, Cytostatics, Siderophores, Pigments, Antibiotics, Immunosuppressants
Peptones	Enzymatic digestion or acid hydrolysis of natural products	Ingredient in bacterial and fungal growth media
Peptide Fragments	Degradation of forensic or paleontological samples by natural effects	Identification or quantification of the source protein

Product and Technology Insights

Convergent synthesis involves the independent synthesis of the peptide sequences, which are connected in the liquid phase by condensation. Many checks must be performed during the peptide synthesis cycle at medium, but mostly to the final product. The ninhydrin test is the most common test of free amino groups due to its tolerance and reproducibility. Enzymes are the cell activation biology catalysts. As such, they need to perform well under the mild cell operating conditions. They must be robust enough to meet harsh conditions of an industrial process, usually involving modification of the enzyme to produce a stable biocatalyst, to become process biocatalysts.

Extensive studies aimed at producing new equipment for peptide synthesis have contributed to this segment's most rapid growth in the global market. The term solid phase peptide synthesis is misleading and gel-phase synthesis is more suitable. In the coming years, recent developments concerning peptide coupling reagents are expected to boost market growth.

End Use Outlook  

Based on end-use the market has e been segmented into therapeutics, diagnosis, and research. Therapeutics segmented has dominated the global end-use market in terms of revenue and is likely to maintain similar trend over the forecast period. Furthermore, diagnosis segment is projected to display fastest growth over the forecast period. Synthesized peptides are commonly used for cancer therapy and have made this segment a significant contributor to therapeutic revenue. Advancement in the manufacturing of peptides that play a key role in metabolic regulations should offer useful insights into the development of effective treatment approaches. Robust growth of the Peptide Therapeutics industry is a key driver for the dominance of end-use companies in the global pharmaceutical & biotechnology market.

Regional Snapshots

In terms of region the global peptide synthesis market is segmented into North America, Europe, Asia Pacific, Central & South America, and Middle East & Africa. Asia Pacific is anticipated to be the fastest growing region over the foreseeable future. Increasing investment by players across outskirts of Asia Pacific coupled with economies of scale is projected to be the key factor for the optimistic market of peptide synthesis across this region.

North America made the most important contribution to the global market, due to the strong presence of major players in the industry, increased awareness of the available peptide synthesis technology and the increasing emphasis on commercially moving peptide products.

Report coverage

The market research study on Peptide Synthesis Market: by Product (Reagents & Consumables, Equipment, Others), Technology (Solid Phase, Liquid Phase, and Hybrid Phase), End User (Therapeutics, Diagnosis, and Research), Geography (North America, Europe, Asia Pacific, Central & South America, Middle East & Africa):-Global Industry Analysis, Market Size, Opportunities and Forecast, 2019 – 2026” offers a detailed insights on the global peptide synthesis market entailing insights on its different market segments. Market dynamics with drivers, restraints and opportunities with their impact are provided in the report. The report provides insights on global peptide synthesis market, its ingredient, product, and major geographic regions. The report covers basic development policies and layouts of technology development processes. Secondly, the report covers global peptide synthesis market size and volume, and segment markets by ingredient, product, and geography along with the information on companies operating in the market. The Peptide Synthesis market analysis is provided for major regional markets including North America, Europe, Asia-Pacific, Latin America, Middle East and Africa. For each region, the market size and volume for different segments has been covered under the scope of report.

Key Players and Strategies

Key players in this market comprise of Bachem Holdings, Biotage, Thermo Fisher, Polypeptide Group, PuroSynth, Syngene, MP Biomedicals, Novo Nordisk A/S, Genscript Biotech, Merck KGaA, etc

The global Peptide Synthesis market is segmented as below:

Market Segmentation

Market By Product

• Reagents & Consumables
• Equipment
• Others

Market By Technology

• Solid Phase
• Liquid Phase
• Hybrid Phase

Market By End-User

• Therapeutics
• Diagnosis
• Research

Market By Geography

• North America
• Europe
• Asia-Pacific
• Latin America
• Middle East and Africa

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