The global nucleic acid isolation and purification market is expected to grow at a CAGR of around 8.8% from 2020 to 2027 and expected to reach the market value of around US$ 7,623.6 Mn by 2027.

A wide range of research and clinical applications necessitate the use of high-quality, pure DNA and RNA. These nucleic acids are isolated from various sources, including cells (including bacterial cells), PCR reactions, restriction enzyme digestions, and agarose gel matrices, to name a few. Purification methods that are optimised for different samples have emerged over time. Changes are made on a regular basis to improve sample quality and yield, shorten processing time, and ensure compatibility with existing workflows and equipment.

Key trends of the global nucleic acid isolation and purification market

Technological advancements support the growth of global nucleic acid isolation and purification market

Nucleic acid-based technologies such as polymerase chain reaction (PCR), DNA microarrays, and high throughput automated sequencing methods outperform culture-based technologies. With the incorporation of and rapid advancements in nucleic acid technologies, particularly next generation sequencing platforms, it can be easily adopted and applied for pathogen detection and diagnosis. Special stains for detecting various cellular components and infectious microbial agents have been developed over the years. This is one of the first areas of laboratory practise to benefit from advances in molecular biology over the last decade. Techniques for isolating and purifying nucleic acids, such as nucleic acid hybridization, polymerase chain reactions, microarray technologies, and rapid high throughput automated sequencing, have gained significant traction in the global market. The incorporation of advanced technologies aids in identifying organisms without the need for special or time-consuming isolation, detecting nonviable organisms, and detecting genetic mutations or alterations in other cellular material, which also represents a significant advantage over traditional classical technologies. Such narrowly focused technologies aid in the detection of nucleic acid molecules and represent newer and more novel methods that are being developed for possible use in clinical laboratories.

Opportunities and strategies to overcome translational challenges to therapeutic nucleic acid nanotechnology

According to ACS Publications statistics, therapeutic nucleic acids (TNAs) have gained significant attention and have accelerated the transition of nucleic acid nanotechnology towards therapeutic applications. The market has been captivated by the remarkable progress made in the development, production, and characterization of nucleic acid nonmaterial’s and nucleic acid nano particles (NANPs). Recent advancements in biosensing, imaging, drug delivery, and immunotherapy have characterized the development of newer strategies. Nucleic acid nano particles are also intended for biosensing, nanoscale material organization, miscomputing, and biocompatible nano scaffolding with embedded functionalities for controlled and targeted delivery to diseased cells and tissues.

Market Dynamics

Rising demand for nucleic acid in the pharmaceutical and biotechnology industries, as well as the increasing utility of nucleic acid-based tests in diagnosis, are factors driving the global market. The increasing application of techniques in a variety of fields such as genetic engineering, life science research, forensics, and molecular diagnostics, as well as government funding for R&D and recent technological innovations, are driving the growth of the global nucleic acid isolation and purification market. Furthermore, the emergence of new technologies in molecular diagnostics, expression analysis, and genotyping will provide suppliers with lucrative opportunities in the future.

Market Segmentation

The global nucleic acid and purification market is segmented based on product, type, method, application, and end-user. By product, the market is segmented as kits, reagents, and instruments. By type, the market is segmented as plasmid DNA isolation and purification, total RNA isolation and purification, circulating nucleic acid isolation and purification, genomic DNA isolation and purification, messenger RNA isolation and purification, microRNA isolation and purification, PCR cleanup, and other nucleic acid isolation and purification types. By method, the market is segmented as column-based isolation and purification, magnetic bead-based isolation and purification, reagent-based isolation and purification, and other isolation and purification methods. By application, the market is segmented as diagnostics, drug discovery & development, personalized medicine, agriculture & animal research, and other applications. By end-user, the market is segmented as Hospitals & diagnostic centers, academic & government research institutes, pharmaceutical & biotechnology companies, contract research organizations, and other end users.

Based on product, kits segment will record remarkable revenue share for the global nucleic acid isolation and purification market. Low cost and easy usage of kits in applications involving gene sequencing, molecular diagnostics, and gene cloning are the factors that contribute for the growth of global nucleic acid isolation and purification market. Based on method, column based isolation and purification records largest market shares in the forecast period. As the method is cost-effective, simpler and faster than organic extraction and incorporation of automation techniques support the growth of the global nucleic acid isolation and purification market. By end-user, hospitals & diagnostic centers is expected to witness highest growth in the forecast period. Rising research activities and the utility of nucleic acid tests in molecular diagnostics are the factors that contribute the growth of the global nucleic acid isolation and purification market.

Regional Landscape

North America is anticipated to hold dominant market share in the forecast period

In the coming years, North America will have the largest market share in the global nucleic acid isolation and purification market. The market's expansion can be attributed to rapid technological advancements, a wide range of nucleic acid applications, and testing in diagnostics, all of which have a positive impact on the global nucleic acid isolation and purification market. A well-established infrastructure also contributes to the expansion of the global nucleic acid isolation and purification market. The increase in R&D funding in biotechnology and healthcare is one of the factors driving the growth of the global nucleic acid isolation and purification market. Asia Pacific, on the other hand, is the most promising market for the growth of the global nucleic acid isolation and purification market.

Competitive Landscape

The prominent players of the global nucleic acid isolation and purification market are QIAGEN, Thermo Fisher Scientific, F. Hoffmann-La Roche AG, and others. Other prominent players involve The Merck Group, Agilent Technologies, Inc., Illumina, Inc., Takara Bio Inc.,  Promega Corporation, GE Healthcare, Danaher Corporation, New England Biolabs, Bio-Rad Laboratories, Inc., and among others

Market Segmentation

Market By Product

Kits
Reagents
Instruments

Market By Type

Plasmid DNA Isolation and Purification
Total RNA Isolation and Purification
Circulating Nucleic Acid Isolation and Purification
Genomic DNA Isolation and Purification
Messenger RNA Isolation and Purification
microRNA Isolation and Purification
PCR Cleanup
Other Nucleic Acid Isolation and Purification Types

Market By Method

Column-based Isolation and Purification
Magnetic Bead-based Isolation and Purification
Reagent-based Isolation and Purification
Other Isolation and Purification Methods

Method By Application

Diagnostics
Drug Discovery & Development
Personalized Medicine
Agriculture & Animal Research
Other Applications

Market By End User

Hospitals & Diagnostic Centers
Academic & Government Research Institutes
Pharmaceutical & Biotechnology Companies
Contract Research Organizations
Other End Users

Market By Geography

North America
•    U.S.
•    Canada

Europe
•    U.K.
•    Germany
•    France
•    Spain
•    Rest of Europe

Asia-Pacific
•    China
•    Japan
•    India
•    Australia
•    South Korea
•    Rest of Asia-Pacific

Latin America
•    Brazil 
•    Mexico
•    Rest of Latin America

Middle East & Africa
•    GCC
•    South Africa
•    Rest of Middle East & Africa

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